Using tiny engineered liver organs derived from human donor cells, researchers found that many genes involved in drug metabolism are under circadian control. These circadian fluctuations affect how much of a drug is available and how effectively the body can break it down. For example, they found that enzymes that break down Tylenol and other […]
Men Versus Women: How Sleep, Circadian Rhythms And Metabolism Differ
A new review of research has examined the key differences in the sleep patterns of women and men, the fluctuations in their body clocks and the impact on their metabolism. The study, published in the journal Sleep Medicine Reviews, highlights the crucial role that gender plays in understanding these factors and suggests that a person’s […]
Infant Gut Microbes Have Their Own Circadian Rhythm And Diet Has Little Influence on How The Microbiome is Composed
The gut microbiome of infants oscillates in a circadian rhythm, even when cultured outside the body. Researchers report in the journal Cell Host & Microbe that this rhythm is detectable as early as two weeks after birth, but becomes more pronounced with increasing age. The findings come from a randomized controlled trial that also showed […]
Study Shows High Prevalence of Hidden Brain Changes in People With Heart Disease
A new analysis involving more than 13,000 people has found that changes to blood vessels in the brain that can increase the risk of stroke and dementia are common in people with a range of heart conditions, regardless of whether they have already had a stroke. The new research, published in Neurology®, the medical journal […]
Heart and Blood Pressure: Are There Differences Between Men and Women?
Using data from mice and humans, a Johns Hopkins Medicine research team has found that a cell surface protein that senses odors and chemicals may be responsible for and explain sex differences in blood pressure in mammals. The unusual link between such protein receptors and sex differences in blood pressure, reported in Science Advances, could […]
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